human MTUS1 shRNA silencing AAV

Name 
AAV-h-MTUS1-shRNA
Cat No 
shAAV-216059
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human MTUS1.

shAAV-216059
AAV-h-MTUS1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MTUS1 (microtubule associated tumor suppressor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
angiotensin-II type 2 receptor-interacting protein; AT2 receptor-binding protein; AT2 receptor-interacting protein; AT2R binding protein; ATBP; ATIP; ATIP3; erythroid differentiation-related; ICIS; microtubule associated tumor suppressor 1; microtubule-associated tumor suppressor 1; Mitochondrial tumor suppressor 1; mitochondrial tumor suppressor gene 1; MP44; MTSG1; transcription factor MTSG1
Description (eCommerce)
The gene for the mitochondrial tumor suppressor 1 (MTUS1) was identified in a chromosomal region frequently deleted in epithelial cancers.
Description (Vector)
MTUS1 encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways.
Gene ID
57509
Gene Name (eCommerce)
microtubule associated scaffold protein 1
Gene Name (Vector)
microtubule associated tumor suppressor 1
Gene Symbol
MTUS1
HGNC ID
HGNC:29789
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3813
ORF Size (bp)
3813 bp
Protein Name (eCommerce)
Microtubule-associated tumor suppressor 1
RefSeq ID
NM_001001924
RefSeq Synonyms
NM_020749, NM_001330470, NM_001166393, NM_001001931, NM_001001925, NM_001001924, BC140068, BC140067, BC136320, BC033842,
Research Areas
Cancer,Cell Cycle,Cytoskeleton,Golgi Apparatus,Mitochondrion,Neurobiology,Signal Transduction,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,neurobiology,signal_transduction
Species
human
Target Sentence
The gene for the mitochondrial tumor suppressor 1 (MTUS1) was identified in a chromosomal region frequently deleted in epithelial cancers.
UniGene ID
Hs.7946
UniProt ID (eCommerce)
Q9ULD2

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.