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human MTA3 shRNA silencing AAV

Name 
AAV-h-MTA3-shRNA
Cat No 
shAAV-215966
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human MTA3.

shAAV-215966
AAV-h-MTA3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MTA3 (metastasis associated 1 family member 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
85
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
metastasis associated gene family, member 3; metastasis-associated protein MTA3
Description (eCommerce)
MTA3 (metastasis-associated protein 3) is a component of the NuRD (nucleosome remodeling and histone deacetylation) complex. MTA3 is a member of a family of proteins (MTA1-3) differentially expressed in metastatic breast cancer cells. MTA3 functions as a repressor of the transcription factor Snail, a factor involved in epithelial to mesenchymal transitions. MTA3 expression is estrogen dependent in breast cancer cells. Studies show that ERalpha selectively bind the MTA3 promoter in an SP1-dependent fashion to stimulate MTA3 gene transcription.
Gene ID
57504
Gene Name (eCommerce)
metastasis associated 1 family member 3
Gene Name (Vector)
metastasis associated 1 family member 3
Gene Symbol
MTA3
HGNC ID
HGNC:23784
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1548
ORF Size (bp)
1548 bp
Protein Name (eCommerce)
Metastasis-associated protein MTA3
RefSeq ID
NM_020744
RefSeq Synonyms
NM_020744, NM_001330444, NM_001330443, NM_001330442, NM_001282756, NM_001282755, BC053631, BC004227,
Research Areas
Breast Cancer,Cancer,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cancer,cell_biology,transcription_translation
Species
human
Target Sentence
MTA3 (metastasis-associated protein 3) is a component of the NuRD (nucleosome remodeling and histone deacetylation) complex. MTA3 is a member of a family of proteins (MTA1-3) differentially expressed in metastatic breast cancer cells. MTA3 functions as a repressor of the transcription factor Snail, a factor involved in epithelial to mesenchymal transitions. MTA3 expression is estrogen dependent in breast cancer cells. Studies show that ERalpha selectively bind the MTA3 promoter in an SP1-dependent fashion to stimulate MTA3 gene transcription.
UniGene ID
Hs.435413
UniProt ID (eCommerce)
Q9BTC8

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.