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human MRVI1 shRNA silencing AAV

Name 
AAV-h-MRVI1-shRNA
Cat No 
shAAV-215883
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human MRVI1.

shAAV-215883
AAV-h-MRVI1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MRVI1 (murine retrovirus integration site 1 homolog). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
IRAG; JAW1L
Description (Vector)
MRVI1 is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used.
Gene ID
10335
Gene Name (Vector)
murine retrovirus integration site 1 homolog
Gene Symbol
MRVI1
HGNC ID
HGNC:7237
ORF Size (aa)
1794
ORF Size (bp)
1794 bp
RefSeq ID
NM_001098579
RefSeq Synonyms
NM_130385, NM_001206881, NM_001206880, NM_001100167, NM_001100163, NM_001098579, BC117127,
Species
human
UniGene ID
Hs.501898

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.