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human MPP5 shRNA silencing AAV

Name 
AAV-h-MPP5-shRNA
Cat No 
shAAV-215722
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human MPP5.

shAAV-215722
AAV-h-MPP5-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MPP5 (membrane palmitoylated protein 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
MAGUK p55 subfamily member 5; membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); PALS1; protein associated with lin seven 1; protein associated with Lin-7 1; stardust
Description (eCommerce)
Membrane palmitoylated protein 5 (MPP5) is a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. MPP5 participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 20237282), and is one of the components of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision (PMID: 22114289) [taken from NCBI Entrez Gene (Gene ID: 64398)].
Description (Vector)
MPP5 encodes a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. The encoded protein participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 20237282), and is one of the components of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision (PMID: 22114289). Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
64398
Gene Name (eCommerce)
membrane palmitoylated protein 5
Gene Name (Vector)
membrane palmitoylated protein 5
Gene Symbol
MPP5
HGNC ID
HGNC:18669
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2028
ORF Size (bp)
2028 bp
Protein Name (eCommerce)
MAGUK p55 subfamily member 5
RefSeq ID
NM_022474
RefSeq Synonyms
NM_022474, NM_001256550, BC129933, BC095485,
Research Areas
Hippo Signaling,Neurobiology,Signal Transduction
Research Areas (Faceted)
neurobiology,signal_transduction
Species
human
Target Sentence
Membrane palmitoylated protein 5 (MPP5) is a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. MPP5 participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 20237282), and is one of the components of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision (PMID: 22114289) [taken from NCBI Entrez Gene (Gene ID: 64398)].
UniGene ID
Hs.652312
UniProt ID (eCommerce)
Q8N3R9

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.