human MOGS shRNA silencing AAV

Name
AAV-h-MOGS-shRNA

Cat No
shAAV-215641

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human MOGS.

shAAV-215641

AAV-h-MOGS-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MOGS (mannosyl-oligosaccharide glucosidase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CDG2B; CWH41; DER7; GCS1

Description (Vector)

MOGS encodes the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. This protein is located in the lumen of the endoplasmic reticulum. Defects in this gene are a cause of type IIb congenital disorder of glycosylation (CDGIIb). Two transcript variants encoding different isoforms have been found for this gene.

Gene ID

7841

Gene Name (Vector)

mannosyl-oligosaccharide glucosidase

Gene Symbol

MOGS

HGNC ID

HGNC:24862

ORF Size (aa)

2514

ORF Size (bp)

2514 bp

RefSeq ID

NM_006302

RefSeq Synonyms

NM_006302, NM_001146158, BC117252, BC117250, BC028337,

Species

human

UniGene ID

Hs.516119

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.