human MNX1 shRNA silencing AAV

Name
AAV-h-MNX1-shRNA

Cat No
shAAV-215619

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human MNX1.

shAAV-215619

AAV-h-MNX1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MNX1 (motor neuron and pancreas homeobox 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

HB9; HLXB9; homeobox HB9; homeobox protein HB9; HOXHB9; motor neuron and pancreas homeobox protein 1; SCRA1

Description (eCommerce)

Homeobox protein HB9 (HLXB9) contains one homeobox DNA-binding domain. HLBX9 is encoded by the motor neuron and pancreas homeobox protein 1 (MNX1) gene. Mutations in MNX1 are the cause of Currarino syndrome and result in presacral tumor, sacral agenesis, and anorectal malformation.

Description (Vector)

MNX1 encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Mutations in this gene result in Currarino syndrome, an autosomic dominant congenital malformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene ID

3110

Gene Name (eCommerce)

motor neuron and pancreas homeobox 1

Gene Name (Vector)

motor neuron and pancreas homeobox 1

Gene Symbol

MNX1

HGNC ID

HGNC:4979

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1206

ORF Size (bp)

1206 bp

Protein Name (eCommerce)

Motor neuron and pancreas homeobox protein 1

RefSeq ID

NM_005515

RefSeq Synonyms

NM_005515, NM_001165255, BC160126,

Research Areas

Axon Guidance,Immunology,Neurobiology,Neurodevelopment,Transcription Factor/Regulator

Research Areas (Faceted)

cell_biology,developmental_biology,immunology,neurobiology,transcription_translation

Species

human

Target Sentence

Homeobox protein HB9 (HLXB9) contains one homeobox DNA-binding domain. HLBX9 is encoded by the motor neuron and pancreas homeobox protein 1 (MNX1) gene. Mutations in MNX1 are the cause of Currarino syndrome and result in presacral tumor, sacral agenesis, and anorectal malformation.

UniGene ID

Hs.37035

UniProt ID (eCommerce)

P50219

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.