human MMP12 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human MMP12.
shAAV-215570
AAV-h-MMP12-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human MMP12 (matrix metallopeptidase 12). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
HME; ME; MME; MMP-12
Description (Vector)
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
Gene ID
4321
Gene Name (Vector)
matrix metallopeptidase 12
Gene Symbol
MMP12
HGNC ID
HGNC:7158
ORF Size (aa)
1413
ORF Size (bp)
1413 bp
RefSeq ID
NM_002426
RefSeq Synonyms
NM_002426, BC143773, BC112301,
Species
human
UniGene ID
Hs.1695
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.