human MLXIP shRNA silencing AAV

Name
AAV-h-MLXIP-shRNA

Cat No
shAAV-215542

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human MLXIP.

shAAV-215542

AAV-h-MLXIP-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MLXIP (MLX interacting protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

80

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

bHLHe36; class E basic helix-loop-helix protein 36; MIR; Mlx interactor; MLX-interacting protein; MONDOA; transcriptional activator MondoA

Description (eCommerce)

MondoA binds DNA as a heterodimer with MLX and activates transcription. MondoA binds to the canonical E box sequence 5'-CACGTG-3'. It plays a role in transcriptional activation of glycolytic target genes and is involved in glucose-responsive gene regulation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9HAP2].

Description (Vector)

MONDOA forms heterodimers with MLX (MIM 602976) that can bind to and activate transcription from CACGTG E boxes (Billin et al., 2000 (PubMed 11073985)).(supplied by OMIM, Mar 2008)

Gene ID

22877

Gene Name (eCommerce)

MLX interacting protein

Gene Name (Vector)

MLX interacting protein

Gene Symbol

MLXIP

HGNC ID

HGNC:17055

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2760

ORF Size (bp)

2760 bp

Protein Name (eCommerce)

MLX-interacting protein

RefSeq ID

NM_014938

RefSeq Synonyms

NM_014938, BC151841, BC039704,

Research Areas

Mitochondrion,Transcription Factor/Regulator

Research Areas (Faceted)

cell_biology,transcription_translation

Species

human

Target Sentence

MondoA binds DNA as a heterodimer with MLX and activates transcription. MondoA binds to the canonical E box sequence 5'-CACGTG-3'. It plays a role in transcriptional activation of glycolytic target genes and is involved in glucose-responsive gene regulation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9HAP2].

UniGene ID

Hs.437153

UniProt ID (eCommerce)

Q9HAP2

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.