human MCOLN2 shRNA silencing AAV

Name
AAV-h-MCOLN2-shRNA

Cat No
shAAV-215198

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human MCOLN2.

shAAV-215198

AAV-h-MCOLN2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MCOLN2 (mucolipin 2). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

TRP-ML2; TRPML2

Description (Vector)

Mucolipins constitute a family of cation channel proteins with homology to the transient receptor potential superfamily. In mammals, the mucolipin family includes 3 members, MCOLN1 (MIM 605248), MCOLN2, and MCOLN3 (MIM 607400), that exhibit a common 6-membrane-spanning topology. Homologs of mammalian mucolipins exist in Drosophila and C. elegans. Mutations in the human MCOLN1 gene cause mucolipodosis IV (MIM 262650) (Karacsonyi et al., 2007 (PubMed 17662026)).(supplied by OMIM, Sep 2009)

Gene ID

255231

Gene Name (Vector)

mucolipin 2

Gene Symbol

MCOLN2

HGNC ID

HGNC:13357

ORF Size (aa)

1701

ORF Size (bp)

1701 bp

RefSeq ID

NM_153259

RefSeq Synonyms

NM_153259, NM_001330647, BC104893, BC104891,

Species

human

UniGene ID

Hs.591446

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.