human MATK shRNA silencing AAV

Name
AAV-h-MATK-shRNA

Cat No
shAAV-215068

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human MATK.

shAAV-215068

AAV-h-MATK-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MATK (megakaryocyte-associated tyrosine kinase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CHK; CTK; HHYLTK; HYL; HYLTK; Lsk

Description (Vector)

MATK has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene.

Gene ID

4145

Gene Name (Vector)

megakaryocyte-associated tyrosine kinase

Gene Symbol

MATK

HGNC ID

HGNC:6906

ORF Size (aa)

1524

ORF Size (bp)

1524 bp

RefSeq ID

NM_002378

RefSeq Synonyms

NM_139355, NM_139354, NM_002378, BC003109, BC000114,

Species

human

UniGene ID

Hs.631845

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.