human MARK2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human MARK2.
shAAV-215037
AAV-h-MARK2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human MARK2 (microtubule affinity regulating kinase 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ELKL motif kinase 1; EMK1; EMK-1; MAP/microtubule affinity-regulating kinase 2; PAR-1; PAR1 homolog; PAR1 homolog b; Par1b; Par-1b; Ser/Thr protein kinase PAR-1B; serine/threonine protein kinase EMK; serine/threonine-protein kinase MARK2; testicular tissue protein Li 117
Description (eCommerce)
MAP/microtubule affinity-regulating kinase 2 (MARK2) is a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes [taken from NCBI Entrez Gene (Gene ID: 2011)].
Description (Vector)
MARK2 encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
2011
Gene Name (eCommerce)
microtubule affinity regulating kinase 2
Gene Name (Vector)
microtubule affinity regulating kinase 2
Gene Symbol
MARK2
HGNC ID
HGNC:3332
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2175
ORF Size (bp)
2175 bp
Protein Name (eCommerce)
Serine/threonine-protein kinase MARK2
RefSeq ID
NM_004954
RefSeq Synonyms
NM_017490, NM_004954, NM_001163297, NM_001163296, NM_001039469, BC084540,
Research Areas
Axonogenesis,Cytoskeleton,Kinase/Phosphatase,LKB1 Signaling,Neurobiology,Neurodevelopment,Notch Signaling,Signal Transduction,TNF Signaling,Wnt Signaling
Research Areas (Faceted)
cell_biology,developmental_biology,neurobiology,signal_transduction
Species
human
Target Sentence
MAP/microtubule affinity-regulating kinase 2 (MARK2) is a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes [taken from NCBI Entrez Gene (Gene ID: 2011)].
UniGene ID
Hs.567261
UniProt ID (eCommerce)
Q7KZI7
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.