human MARCH4 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human MARCH4.
shAAV-215020
AAV-h-MARCH4-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human MARCH4 (membrane associated ring-CH-type finger 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
MARCH-IV; RNF174
Description (Vector)
MARCH4 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH4 reduces surface accumulation of several membrane glycoproteins by directing them to the endosomal compartment (Bartee et al., 2004 (PubMed 14722266)).(supplied by OMIM, Apr 2010)
Gene ID
57574
Gene Name (Vector)
membrane associated ring-CH-type finger 4
Gene Symbol
4-Mar
HGNC ID
HGNC:29269
ORF Size (aa)
1233
ORF Size (bp)
1233 bp
RefSeq ID
NM_020814
RefSeq Synonyms
NM_020814, BC098448,
Species
human
UniGene ID
Hs.170388
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.