human MAPK8IP2 shRNA silencing AAV

Name
AAV-h-MAPK8IP2-shRNA

Cat No
shAAV-214989

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human MAPK8IP2.

shAAV-214989

AAV-h-MAPK8IP2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MAPK8IP2 (mitogen-activated protein kinase 8 interacting protein 2). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

IB-2; IB2; JIP2; PRKM8IPL

Description (Vector)

MAPK8IP2 is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.

Gene ID

23542

Gene Name (Vector)

mitogen-activated protein kinase 8 interacting protein 2

Gene Symbol

MAPK8IP2

HGNC ID

HGNC:6883

ORF Size (aa)

2475

ORF Size (bp)

2475 bp

RefSeq ID

NM_012324

RefSeq Synonyms

NM_016431, NM_012324, BC047527, BC009940,

Species

human

UniGene ID

Hs.558180

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.