human MAPK8 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human MAPK8.
shAAV-214985
AAV-h-MAPK8-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human MAPK8 (mitogen-activated protein kinase 8). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; PRKM8; SAPK1; SAPK1c
Description (Vector)
MAPK8 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Gene ID
5599
Gene Name (Vector)
mitogen-activated protein kinase 8
Gene Symbol
MAPK8
HGNC ID
HGNC:6881
ORF Size (aa)
1155
ORF Size (bp)
1155 bp
RefSeq ID
NM_139049
RefSeq Synonyms
NM_139049, NM_139047, NM_139046, NM_002750, NM_001323331, NM_001323330, NM_001323329, NM_001323328, NM_001323327, NM_001323326, NM_001323325, NM_001323324, NM_001323323, NM_001323322, NM_001323321, NM_001323320, NM_001323302, NM_001278548, NM_001278547, BC144063, BC130572, BC130570,
Species
human
UniGene ID
Hs.138211
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.