human MAPK10 shRNA silencing AAV

Name
AAV-h-MAPK10-shRNA

Cat No
shAAV-214967

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human MAPK10.

shAAV-214967

AAV-h-MAPK10-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MAPK10 (mitogen-activated protein kinase 10). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

JNK3; JNK3A; p493F12; p54bSAPK; PRKM10; SAPK1b

Description (Vector)

MAPK10 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Gene ID

5602

Gene Name (Vector)

mitogen-activated protein kinase 10

Gene Symbol

MAPK10

HGNC ID

HGNC:6872

ORF Size (aa)

1395

ORF Size (bp)

1395 bp

RefSeq ID

NM_002753

RefSeq Synonyms

NM_138982, NM_138981, NM_138980, NM_002753, NM_001318069, NM_001318068, NM_001318067, BC065516, BC051731, BC035057,

Species

human

UniGene ID

Hs.125503

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.