human MAP2K3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human MAP2K3.
shAAV-214917
AAV-h-MAP2K3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human MAP2K3 (mitogen-activated protein kinase kinase 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
MAPKK3; MEK3; MKK3; PRKMK3; SAPKK-2; SAPKK2
Description (Vector)
MAP2K3 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.
Gene ID
5606
Gene Name (Vector)
mitogen-activated protein kinase kinase 3
Gene Symbol
MAP2K3
HGNC ID
HGNC:6843
ORF Size (aa)
1044
ORF Size (bp)
1044 bp
RefSeq ID
NM_002756
RefSeq Synonyms
NM_145109, NM_002756, NM_001316332, BC032478,
Species
human
UniGene ID
Hs.514012
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.