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human MAP2 shRNA silencing AAV

Name 
AAV-h-MAP2-shRNA
Cat No 
shAAV-214912
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human MAP2.

shAAV-214912
AAV-h-MAP2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MAP2 (microtubule associated protein 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
MAP-2; MAP2A; MAP2B; MAP2C; microtubule-associated protein 2
Description (eCommerce)
Microtubule-associated protein 2 (MAP2) belongs to the MAP family of microtubule assembly proteins. MAP2 is expressed mainly in neurons and is important to neurogenesis. In addition to binding microtubules, MAP2 can also bind F-actin and bundle actin filaments. This function, as well as its role as an adaptor protein in PKA signaling, appears to be important to the initiation of neurite extension. As a structural MAP, MAP2 interacts with a multitude of proteins and associates with a number of protein kinases indicating its importance in linking cell signaling and cytoskeletal organization.
Description (Vector)
MAP2 encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described.
Gene ID
4133
Gene Name (eCommerce)
microtubule associated protein 2
Gene Name (Vector)
microtubule associated protein 2
Gene Symbol
MAP2
HGNC ID
HGNC:6839
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
5481
ORF Size (bp)
5481 bp
Protein Name (eCommerce)
Microtubule-associated protein 2
RefSeq ID
NM_002374
RefSeq Synonyms
NM_031847, NM_031845, NM_002374, NM_001039538, BC172568, BC172263, BC038857,
Research Areas
Axonogenesis,Cytoskeleton,LKB1 Signaling,MAPK Signaling,Neurobiology,Neurodevelopment,Signal Transduction
Research Areas (Faceted)
signal_transduction,neurobiology,developmental_biology,cell_biology,signal_transduction,neurobiology,developmental_biology
Species
human
Target Sentence
Microtubule-associated protein 2 (MAP2) belongs to the MAP family of microtubule assembly proteins. MAP2 is expressed mainly in neurons and is important to neurogenesis. In addition to binding microtubules, MAP2 can also bind F-actin and bundle actin filaments. This function, as well as its role as an adaptor protein in PKA signaling, appears to be important to the initiation of neurite extension. As a structural MAP, MAP2 interacts with a multitude of proteins and associates with a number of protein kinases indicating its importance in linking cell signaling and cytoskeletal organization.
UniGene ID
Hs.368281
UniProt ID (eCommerce)
P11137

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.