human MAD2L1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human MAD2L1.
shAAV-214775
AAV-h-MAD2L1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human MAD2L1 (MAD2 mitotic arrest deficient-like 1 (yeast)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
HSMAD2; MAD2; MAD2 (mitotic arrest deficient, yeast, homolog)-like 1; MAD2 mitotic arrest deficient-like 1; MAD2-like protein 1; mitotic arrest deficient 2-like protein 1; mitotic arrest deficient, yeast, homolog-like 1; mitotic spindle assembly checkpoint protein MAD2A
Description (eCommerce)
MAD2 (Mitotic Arrest Deficiency 2) is a component of the mitotic spindle-assembly checkpoint that ensures that all chromosomes are aligned at the metaphase plate before the onset of anaphase. MAD2 is a subunit of the MCC complex that includes BubR1, Bub3, Cdc20 and Mad2, which may function to inhibit the APC/c (Anaphase Promoting Complex/Cyclosome). MAD2 is regulated by MAD1.
Description (Vector)
MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14.
Gene ID
4085
Gene Name (eCommerce)
mitotic arrest deficient 2 like 1
Gene Name (Vector)
MAD2 mitotic arrest deficient-like 1 (yeast)
Gene Symbol
MAD2L1
HGNC ID
HGNC:6763
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
618
Protein Name (eCommerce)
Mitotic spindle assembly checkpoint protein MAD2A
RefSeq ID
NM_002358
RefSeq Synonyms
NM_002358, BC070283, BC005945, BC000356,
Research Areas
Apoptosis,Cell Cycle,Cell Division,Cytoskeleton,Host-Virus Interactions,Meiosis,SCF-KIT Signaling,Signal Transduction
Research Areas (Faceted)
cell_biology,cell_cycle,developmental_biology,genetics,infectious_disease,signal_transduction,stem_cell_biology
Species
human
Target Sentence
MAD2 (Mitotic Arrest Deficiency 2) is a component of the mitotic spindle-assembly checkpoint that ensures that all chromosomes are aligned at the metaphase plate before the onset of anaphase. MAD2 is a subunit of the MCC complex that includes BubR1, Bub3, Cdc20 and Mad2, which may function to inhibit the APC/c (Anaphase Promoting Complex/Cyclosome). MAD2 is regulated by MAD1.
UniGene ID
Hs.591697
UniProt ID (eCommerce)
Q13257
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.