human M6PRBP1 shRNA silencing AAV

Name 
AAV-h-M6PRBP1-shRNA
Cat No 
shAAV-214762
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human PLIN3.

shAAV-214762
AAV-h-M6PRBP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PLIN3 (perilipin 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
50
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
47 kDa mannose 6-phosphate receptor-binding protein; 47 kDa MPR-binding protein; cargo selection protein TIP47; M6PRBP1; mannose-6-phosphate receptor-binding protein 1; perilipin-3; placental protein 17; PP17; tail-interacting protein, 47 kD; testicular tissue protein Li 114; TIP47
Description (eCommerce)
Perilipin-3 is required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O60664].
Description (Vector)
Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
10226
Gene Name (eCommerce)
perilipin 3
Gene Name (Vector)
perilipin 3
Gene Symbol
PLIN3
HGNC ID
HGNC:16893
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1305
ORF Size (bp)
1305 bp
Protein Name (eCommerce)
Perilipin-3
RefSeq ID
NM_005817
RefSeq Synonyms
NM_005817, NM_001164194, NM_001164189, BC019278, BC007566, BC005818, BC001590,
Research Areas
Golgi Apparatus
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
Perilipin-3 is required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O60664].
UniGene ID
Hs.140452
UniProt ID (eCommerce)
O60664

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.