human LOC25845 shRNA silencing AAV

Name
AAV-h-LOC25845-shRNA

Cat No
shAAV-214221

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human EXOC3.

shAAV-214221

AAV-h-LOC25845-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human EXOC3 (exocyst complex component 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

SEC6; SEC6L1; Sec6p

Description (Vector)

EXOC3 is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity.

Gene ID

11336

Gene Name (Vector)

exocyst complex component 3

Gene Symbol

EXOC3

HGNC ID

HGNC:30378

ORF Size (aa)

2238

ORF Size (bp)

2238 bp

RefSeq ID

NM_007277

RefSeq Synonyms

NM_007277, BC064569,

Species

human

UniGene ID

Hs.481464

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.