human SNAP25 shRNA silencing AAV

Name
AAV-h-SNAP25-shRNA

Cat No
shAAV-214114

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human SNAP25.

shAAV-214114

AAV-h-SNAP25-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SNAP25 (synaptosome associated protein 25). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

bA416N4.2; CMS18; dJ1068F16.2; RIC-4; RIC4; SEC9; SNAP; SNAP-25; SUP

Description (Vector)

Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene.

Gene ID

6616

Gene Name (Vector)

synaptosome associated protein 25

Gene Symbol

SNAP25

HGNC ID

HGNC:11132

ORF Size (aa)

621

RefSeq ID

NM_003081

RefSeq Synonyms

NM_130811, NM_003081, NM_001322910, NM_001322909, NM_001322908, NM_001322907, NM_001322906, NM_001322905, NM_001322904, NM_001322903, NM_001322902, BC010647,

Species

human

UniGene ID

Hs.167317

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.