human LEPREL1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human P3H2.
shAAV-213836
AAV-h-LEPREL1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human P3H2 (prolyl 3-hydroxylase 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
LEPREL1; MCVD; MLAT4
Description (Vector)
LEPREL1 encodes a member of the prolyl 3-hydroxylase subfamily of 2-oxo-glutarate-dependent dioxygenases. These enzymes play a critical role in collagen chain assembly, stability and cross-linking by catalyzing post-translational 3-hydroxylation of proline residues. Mutations in this gene are associated with nonsyndromic severe myopia with cataract and vitreoretinal degeneration, and downregulation of this gene may play a role in breast cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Gene ID
55214
Gene Name (Vector)
prolyl 3-hydroxylase 2
Gene Symbol
P3H2
HGNC ID
HGNC:19317
ORF Size (aa)
1584
ORF Size (bp)
1584 bp
RefSeq ID
NM_018192
RefSeq Synonyms
NM_018192, NM_001134418, BC005029,
Species
human
UniGene ID
Hs.374191
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.