human LEP shRNA silencing AAV

Name
AAV-h-LEP-shRNA

Cat No
shAAV-213830

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human LEP.

shAAV-213830

AAV-h-LEP-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human LEP (leptin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

LEPD; OB; OBS

Description (Vector)

LEP encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. LEP has also been linked to type 2 diabetes mellitus development.

Gene ID

3952

Gene Name (Vector)

leptin

Gene Symbol

LEP

HGNC ID

HGNC:6553

ORF Size (aa)

504

RefSeq ID

NM_000230

RefSeq Synonyms

NM_000230, BC069527, BC069452, BC069323, BC060830,

Species

human

UniGene ID

Hs.194236

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.