human LEMD3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human LEMD3.
shAAV-213821
AAV-h-LEMD3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human LEMD3 (LEM domain containing 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
inner nuclear membrane protein Man1; integral inner nuclear membrane protein; LEM domain-containing protein 3; LEMD3/MKX fusion; MAN1
Description (eCommerce)
LEM domain-containing protein 3 (LEMD3) can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. LEMD3 antagonizes TGF-beta-induced cell proliferation arrest [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y2U8].
Description (Vector)
This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.
Gene ID
23592
Gene Name (eCommerce)
LEM domain containing 3
Gene Name (Vector)
LEM domain containing 3
Gene Symbol
LEMD3
HGNC ID
HGNC:28887
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2736
ORF Size (bp)
2736 bp
Protein Name (eCommerce)
Inner nuclear membrane protein Man1
RefSeq ID
NM_014319
RefSeq Synonyms
NM_014319, NM_001167614, BC167864,
Research Areas
Cell Cycle
Research Areas (Faceted)
cell_biology,cell_cycle,genetics
Species
human
Target Sentence
LEM domain-containing protein 3 (LEMD3) can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. LEMD3 antagonizes TGF-beta-induced cell proliferation arrest [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y2U8].
UniGene ID
Hs.718513
UniProt ID (eCommerce)
Q9Y2U8
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.