human LEF1 shRNA silencing AAV

Name
AAV-h-LEF1-shRNA

Cat No
shAAV-213813

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human LEF1.

shAAV-213813

AAV-h-LEF1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human LEF1 (lymphoid enhancer binding factor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

LEF-1; lymphoid enhancer-binding factor 1; T cell-specific transcription factor 1-alpha; TCF10; TCF1ALPHA; TCF1-alpha; TCF7L3

Description (eCommerce)

Lymphoid enhancer-binding factor 1 (LEF1) is transcription factor involved in the Wnt signaling pathway. In cooperation with beta-catenin it activates transcription of target genes critical to development.

Description (Vector)

LEF1 encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. LEF1 has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants.

Gene ID

51176

Gene Name (eCommerce)

lymphoid enhancer binding factor 1

Gene Name (Vector)

lymphoid enhancer binding factor 1

Gene Symbol

LEF1

HGNC ID

HGNC:6551

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1200

ORF Size (bp)

1200 bp

Protein Name (eCommerce)

Lymphoid enhancer-binding factor 1

RefSeq ID

NM_016269

RefSeq Synonyms

NM_016269, NM_001166119, NM_001130714, NM_001130713, BC050632, BC040559,

Research Areas

Angiogenesis,Apoptosis,Brain Development,Cancer,Cardiology,Cardiomyopathy,Cardiovascular,Cell Cycle,Colorectal Cancer,Estrogen Signaling,Gene Expression,Hippo Signaling,Histone Modification,Host-Virus Interactions,Immunology,Interleukin Signaling,Leukemia,Neurobiology,Neurodevelopment,Neurogenesis,Notch Signaling,Nuclear Receptor Coactivators,Prostate Cancer,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator,Wnt Signaling

Research Areas (Faceted)

cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,neurobiology,signal_transduction,transcription_translation

Species

human

Target Sentence

UniGene ID

Hs.555947

UniProt ID (eCommerce)

Q9UJU2

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.