human LDLR shRNA silencing AAV

Name 
AAV-h-LDLR-shRNA
Cat No 
shAAV-213796
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human LDLR.

shAAV-213796
AAV-h-LDLR-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human LDLR (low density lipoprotein receptor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
FH; FHC; LDL receptor; LDLCQ2; low-density lipoprotein receptor; low-density lipoprotein receptor class A domain-containing protein 3
Description (eCommerce)
Low-density lipoprotein receptor, LDLR, binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, LDLR functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cell [taken from NCBI Entrez Gene (Gene ID: 3949)].
Description (Vector)
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.
Gene ID
3949
Gene Name (eCommerce)
low density lipoprotein receptor
Gene Name (Vector)
low density lipoprotein receptor
Gene Symbol
LDLR
HGNC ID
HGNC:6547
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2583
ORF Size (bp)
2583 bp
Protein Name (eCommerce)
Low-density lipoprotein receptor
RefSeq ID
NM_000527
RefSeq Synonyms
NM_001195803, NM_001195802, NM_001195800, NM_001195799, NM_001195798, NM_000527, BC014514,
Research Areas
Aging,DNA Damage/Repair,EGFR Signaling,Golgi Apparatus,Host-Virus Interactions,Lysosome,Metabolism/Metabolic Process,Neurobiology,Signal Transduction,Wnt Signaling
Research Areas (Faceted)
cell_biology,genetics,infectious_disease,metabolism,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
Low-density lipoprotein receptor, LDLR, binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, LDLR functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cell [taken from NCBI Entrez Gene (Gene ID: 3949)].
UniGene ID
Hs.713967
UniProt ID (eCommerce)
P01130

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.