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human KRT6A shRNA silencing AAV

Name 
AAV-h-KRT6A-shRNA
Cat No 
shAAV-213433
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human KRT6A.

shAAV-213433
AAV-h-KRT6A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human KRT6A (keratin 6A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
allergen Hom s 5;CK6A;CK-6A;CK6C;CK-6C;CK6D;CK-6D;CK-6E;cytokeratin 6A;cytokeratin 6C;cytokeratin 6D;Cytokeratin-6A;Cytokeratin-6D;K6A;K6C;K6D;keratin 6A, , type II;keratin 6A, type II;keratin, epidermal type II, K6A;keratin, type II cytoskeletal 6A;keratin, type II cytoskeletal 6C;Keratin-6A;KRT6C;KRT6D;PC3;type-II keratin Kb6
Description (Vector)
KRT6A is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
Gene ID
3853
Gene Name (eCommerce)
keratin 6A
Gene Name (Vector)
keratin 6A
Gene Symbol
KRT6A
HGNC ID
HGNC:6443
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1695
ORF Size (bp)
1695 bp
Protein Name (eCommerce)
Keratin, type II cytoskeletal 6A
RefSeq ID
NM_005554
RefSeq Synonyms
NM_005554, BC139753, BC125058, BC069269, BC014152, BC008807,
Research Areas (Faceted)
cell_biology,metabolism,signal_transduction
Species
human
UniGene ID
Hs.700779
UniProt ID (eCommerce)
P02538

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.