human KREMEN1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human KREMEN1.
shAAV-213364
AAV-h-KREMEN1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human KREMEN1 (kringle containing transmembrane protein 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
KREMEN; KRM1
Description (Vector)
KREMEN1 encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.
Gene ID
83999
Gene Name (Vector)
kringle containing transmembrane protein 1
Gene Symbol
KREMEN1
HGNC ID
HGNC:17550
ORF Size (aa)
1377
ORF Size (bp)
1377 bp
RefSeq ID
NM_032045
RefSeq Synonyms
NM_032045, NM_001039570, BC063787,
Species
human
UniGene ID
Hs.229335
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.