human KLRD1 shRNA silencing AAV

Name 
AAV-h-KLRD1-shRNA
Cat No 
shAAV-213324
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human KLRD1.

shAAV-213324
AAV-h-KLRD1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human KLRD1 (killer cell lectin like receptor D1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CD antigen CD94; CD94; CD94 antigen; Killer cell lectin-like receptor subfamily D member 1; killer cell lectin-like receptor subfamily D, member 1; KP43; natural killer cells antigen CD94; NK cell receptor
Description (eCommerce)
KLRD1 (CD94) is an immune receptor preferentially expressed on Natural killer (NK) cells, a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. CD94 is one of several genes of the C-type lectin superfamily expressed by NK cells that are involved in the regulation of NK cell function including self-nonself discrimination. [taken from NCBI Entrez Gene (Gene ID: 3824)].
Description (Vector)
Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Three transcript variants encoding two different isoforms have been found for this gene.
Gene ID
3824
Gene Name (eCommerce)
killer cell lectin like receptor D1
Gene Name (Vector)
killer cell lectin like receptor D1
Gene Symbol
KLRD1
HGNC ID
HGNC:6378
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
540
Protein Name (eCommerce)
Natural killer cells antigen CD94
RefSeq ID
NM_002262
RefSeq Synonyms
NM_007334, NM_002262, NM_001114396, BC028009,
Research Areas
Antigen Processing and Presentation,Immunology,Innate Immunity
Research Areas (Faceted)
immunology
Species
human
Target Sentence
KLRD1 (CD94) is an immune receptor preferentially expressed on Natural killer (NK) cells, a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. CD94 is one of several genes of the C-type lectin superfamily expressed by NK cells that are involved in the regulation of NK cell function including self-nonself discrimination. [taken from NCBI Entrez Gene (Gene ID: 3824)].
UniGene ID
Hs.562457
UniProt ID (eCommerce)
Q13241

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.