human KIR2DL5A shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human KIR2DL5A.
shAAV-213130
AAV-h-KIR2DL5A-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human KIR2DL5A (killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CD158F; KIR2DL5; KIR2DL5.1; KIR2DL5.3
Description (Vector)
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
Gene ID
57292
Gene Name (Vector)
killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A
Gene Symbol
KIR2DL5A
HGNC ID
HGNC:16345
ORF Size (aa)
1128
ORF Size (bp)
1128 bp
RefSeq ID
NM_020535
RefSeq Synonyms
NM_020535, BC160063,
Species
human
UniGene ID
Hs.676464
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.