human KIAA0415 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human AP5Z1.
shAAV-212913
AAV-h-KIAA0415-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human AP5Z1 (adaptor related protein complex 5 zeta 1 subunit). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
KIAA0415; SPG48; zeta
Description (Vector)
AP5Z1 was identified by genome-wide screen for genes involved in homologous recombination DNA double-strand break repair (HR-DSBR). The encoded protein was found in a complex with other proteins that have a role in HR-DSBR. Knockdown of this gene reduced homologous recombination, and mutations in this gene were found in patients with spastic paraplegia. It was concluded that this gene likely encodes a helicase (PMID:20613862).
Gene ID
9907
Gene Name (Vector)
adaptor related protein complex 5 zeta 1 subunit
Gene Symbol
AP5Z1
HGNC ID
HGNC:22197
ORF Size (aa)
1341
ORF Size (bp)
1341 bp
RefSeq ID
NM_014855
RefSeq Synonyms
NM_014855, BC037399,
Species
human
UniGene ID
Hs.558440
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.