human DPYD Over-expression AAV
This is an AAV expressing Human DPYD.
AAV-207307
AAV-h-DPYD
Ready-to-use AAV expressing Human DPYD (dihydropyrimidine dehydrogenase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DHP; DHPDHASE; DPD
Description (Vector)
DPYD is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
1806
Gene Name (Vector)
dihydropyrimidine dehydrogenase
Gene Symbol
DPYD
HGNC ID
HGNC:3012
ORF Size (aa)
3078
ORF Size (bp)
3078 bp
RefSeq ID
NM_000110
RefSeq Synonyms
NM_001160301, NM_000110, BC131778, BC131777, BC008379,
Species
human
UniGene ID
Hs.335034
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.