human KCNA4 shRNA silencing AAV

Name
AAV-h-KCNA4-shRNA

Cat No
shAAV-212654

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human KCNA4.

shAAV-212654

AAV-h-KCNA4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human KCNA4 (potassium voltage-gated channel subfamily A member 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

HBK4; HK1; HPCN2; HUKII; KCNA4L; KCNA8; KV1.4; PCN2

Description (Vector)

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influence the duration of cardiac action potential.

Gene ID

3739

Gene Name (Vector)

potassium voltage-gated channel subfamily A member 4

Gene Symbol

KCNA4

HGNC ID

HGNC:6222

ORF Size (aa)

1962

ORF Size (bp)

1962 bp

RefSeq ID

NM_002233

RefSeq Synonyms

NM_002233, BC166685,

Species

human

UniGene ID

Hs.592002

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.