human INVS shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human INVS.
shAAV-212333
AAV-h-INVS-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human INVS (inversin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
INV; NPH2; NPHP2
Description (Vector)
INVS encodes a protein containing multiple ankyrin domains and two IQ calmodulin-binding domains. The encoded protein may function in renal tubular development and function, and in left-right axis determination. This protein interacts with nephrocystin and infers a connection between primary cilia function and left-right axis determination. A similar protein in mice interacts with calmodulin. Mutations in this gene have been associated with nephronophthisis type 2. Multiple transcript variants encoding distinct isoforms have been identified for this gene.
Gene ID
27130
Gene Name (Vector)
inversin
Gene Symbol
INVS
HGNC ID
HGNC:17870
ORF Size (aa)
3198
ORF Size (bp)
3198 bp
RefSeq ID
NM_014425
RefSeq Synonyms
NM_183245, NM_014425, NM_001318382, NM_001318381, BC112351, BC111761,
Species
human
UniGene ID
Hs.558477
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.