human INPPL1 shRNA silencing AAV

Name 
AAV-h-INPPL1-shRNA
Cat No 
shAAV-212297
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human INPPL1.

shAAV-212297
AAV-h-INPPL1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human INPPL1 (inositol polyphosphate phosphatase like 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
51C protein; Inositol polyphosphate phosphatase-like protein 1; INPPL-1; OPSMD; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; protein 51C; SH2 domain-containing inositol 5'-phosphatase 2; SH2 domain-containing inositol phosphatase 2; SH2 domain-containing inositol-5'-phosphatase 2; SHIP2; SHIP-2
Description (eCommerce)
INPPL1 (Inositol Polyphosphate Phosphatase-Like Protein 1) is a phosphatidylinositol phosphatase that negatively regulates phosphoinositide 3-kinase (PI3K) pathways related to numerous cell activities. INPPL1 plays a role in PI3K-dependent insulin, macrophage colony-stimulating factor, and EGF signaling. INPPL1 is also involved in actin cytoskeletal remodeling, actin dynamics, and neuritogenesis. INPPL1 interacts with SHC1 (src-homology domain) to mediate EGFR signaling.
Description (Vector)
INPPL1 is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer.
Gene ID
3636
Gene Name (eCommerce)
inositol polyphosphate phosphatase like 1
Gene Name (Vector)
inositol polyphosphate phosphatase like 1
Gene Symbol
INPPL1
HGNC ID
HGNC:6080
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3777
ORF Size (bp)
3777 bp
Protein Name (eCommerce)
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
RefSeq ID
NM_001567
RefSeq Synonyms
NM_001567, BC140853,
Research Areas
B-cell Receptor Signaling,Brain Development,Cytokine Signaling,Cytoskeleton,DNA Replication,EGFR Signaling,Gene Expression,Golgi Apparatus,HGF Signaling,Immunology,Insulin Signaling,Interleukin Signaling,Kinase/Phosphatase,Metabolism/Metabolic Process,mTOR Signaling,Neurobiology,Neurodevelopment,Signal Transduction
Research Areas (Faceted)
cell_biology,developmental_biology,genetics,transcription_translation,immunology,metabolism,neurobiology,signal_transduction
Species
human
Target Sentence
INPPL1 (Inositol Polyphosphate Phosphatase-Like Protein 1) is a phosphatidylinositol phosphatase that negatively regulates phosphoinositide 3-kinase (PI3K) pathways related to numerous cell activities. INPPL1 plays a role in PI3K-dependent insulin, macrophage colony-stimulating factor, and EGF signaling. INPPL1 is also involved in actin cytoskeletal remodeling, actin dynamics, and neuritogenesis. INPPL1 interacts with SHC1 (src-homology domain) to mediate EGFR signaling.
UniGene ID
Hs.523875
UniProt ID (eCommerce)
O15357

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.