human ING3 shRNA silencing AAV

Name
AAV-h-ING3-shRNA

Cat No
shAAV-212264

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human ING3.

shAAV-212264

AAV-h-ING3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ING3 (inhibitor of growth family member 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

Eaf4; ING2; MEAF4; p47ING3

Description (Vector)

ING3 is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.

Gene ID

54556

Gene Name (Vector)

inhibitor of growth family member 3

Gene Symbol

ING3

HGNC ID

HGNC:14587

ORF Size (aa)

1257

ORF Size (bp)

1257 bp

RefSeq ID

NM_019071

RefSeq Synonyms

NM_198267, NM_019071, BC153171, BC146417, BC073865,

Species

human

UniGene ID

Hs.489811

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.