human IL8RA shRNA silencing AAV

Name
AAV-h-IL8RA-shRNA

Cat No
shAAV-212213

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CXCR1.

shAAV-212213

AAV-h-IL8RA-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CXCR1 (C-X-C motif chemokine receptor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

C-C; C-C-CKR-1; CD128; CD181; CDw128a; CKR-1; CMKAR1; IL8R1; IL8RA; IL8RBA

Description (Vector)

CXCR1 is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36.

Gene ID

3577

Gene Name (Vector)

C-X-C motif chemokine receptor 1

Gene Symbol

CXCR1

HGNC ID

HGNC:6026

ORF Size (aa)

1053

ORF Size (bp)

1053 bp

RefSeq ID

NM_000634

RefSeq Synonyms

NM_000634, BC072397, BC028221,

Species

human

UniGene ID

Hs.194778

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.