human IL18BP shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human IL18BP.
shAAV-212076
AAV-h-IL18BP-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human IL18BP (interleukin 18 binding protein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
IL18BPa
Description (Vector)
IL18BP functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Gene ID
10068
Gene Name (Vector)
interleukin 18 binding protein
Gene Symbol
IL18BP
HGNC ID
HGNC:5987
ORF Size (aa)
585
RefSeq ID
NM_173042
RefSeq Synonyms
NM_173044, NM_173042, NM_005699, NM_001145057, NM_001145055, NM_001039660, NM_001039659, BC044215,
Species
human
UniGene ID
Hs.591967
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.