human IL12RB2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human IL12RB2.
shAAV-212037
AAV-h-IL12RB2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human IL12RB2 (interleukin 12 receptor subunit beta 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
IL12RB2 is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene.
Gene ID
3595
Gene Name (Vector)
interleukin 12 receptor subunit beta 2
Gene Symbol
IL12RB2
HGNC ID
HGNC:5972
ORF Size (aa)
2331
ORF Size (bp)
2331 bp
RefSeq ID
NM_001559
RefSeq Synonyms
NM_001559, NM_001319233, NM_001258216, NM_001258215, NM_001258214, BC143249, BC104774, BC104772,
Species
human
UniGene ID
Hs.479347
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.