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human IL12B shRNA silencing AAV

Name 
AAV-h-IL12B-shRNA
Cat No 
shAAV-212029
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human IL12B.

shAAV-212029
AAV-h-IL12B-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human IL12B (interleukin 12B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CLMF;CLMF p40;CLMF2;cytotoxic lymphocyte maturation factor 40 kDa subunit;IL-12 subunit p40;IL12, subunit p40;IL-12B;IMD28;IMD29;interleukin 12, p40;interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40);interleukin-12 beta chain;interleukin-12 subunit beta;natural killer cell stimulatory factor, 40 kD subunit;NK cell stimulatory factor chain 2;NKSF;NKSF2
Description (eCommerce)
IL-12B is a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD IL-12B, and the 35 kD subunit IL-12A. IL-12 is expressed by activated macrophages that serve as an essential inducer of Th1 cells development, and has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. [provided by RefSeq, Jul 2008; taken from NCBI Entrez Gene (Gene ID: 3593)].
Description (Vector)
IL12B encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.
Gene ID
3593
Gene Name (eCommerce)
interleukin 12B
Gene Name (Vector)
interleukin 12B
Gene Symbol
IL12B
HGNC ID
HGNC:5970
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
987
ORF Size (bp)
987 bp
Protein Name (eCommerce)
Interleukin-12 subunit beta
RefSeq ID
NM_002187
RefSeq Synonyms
NM_002187, BC074723, BC067502, BC067501, BC067500, BC067499, BC067498,
Research Areas
Apoptosis,Cancer,Cell Cycle,GPCR Signaling,Host-Virus Interactions,IFN Signaling,Immunology,Interleukin Signaling,JAK-STAT Signaling,Signal Transduction,Toll-like Receptor Signaling
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,immunology,infectious_disease,signal_transduction
Species
human
Target Sentence
IL-12B is a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD IL-12B, and the 35 kD subunit IL-12A. IL-12 is expressed by activated macrophages that serve as an essential inducer of Th1 cells development, and has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. [provided by RefSeq, Jul 2008; taken from NCBI Entrez Gene (Gene ID: 3593)].
UniGene ID
Hs.674
UniProt ID (eCommerce)
P29460

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.