human IKZF3 shRNA silencing AAV

Name
AAV-h-IKZF3-shRNA

Cat No
shAAV-212019

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human IKZF3.

shAAV-212019

AAV-h-IKZF3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human IKZF3 (IKAROS family zinc finger 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AIO; AIOLOS; ZNFN1A3

Description (Vector)

IKZF3 encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. IKZF3 product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants.

Gene ID

22806

Gene Name (Vector)

IKAROS family zinc finger 3

Gene Symbol

IKZF3

HGNC ID

HGNC:13178

ORF Size (aa)

1530

ORF Size (bp)

1530 bp

RefSeq ID

NM_012481

RefSeq Synonyms

NM_183232, NM_183231, NM_183230, NM_183229, NM_183228, NM_012481, NM_001284516, NM_001284515, NM_001284514, NM_001257414, NM_001257413, NM_001257412, NM_001257411, NM_001257410, NM_001257409, NM_001257408, BC032707,

Species

human

UniGene ID

Hs.444388

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.