human IKBKG shRNA silencing AAV

Name
AAV-h-IKBKG-shRNA

Cat No
shAAV-212012

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human IKBKG.

shAAV-212012

AAV-h-IKBKG-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human IKBKG (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AMCBX1; FIP-3; FIP3; Fip3p; IKK-gamma; IKKAP1; IKKG; IMD33; IP; IP1; IP2; IPD2; NEMO; ZC2HC9

Description (Vector)

IKBKG encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome.

Gene ID

8517

Gene Name (Vector)

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma

Gene Symbol

IKBKG

HGNC ID

HGNC:5961

ORF Size (aa)

1260

ORF Size (bp)

1260 bp

RefSeq ID

NM_003639

RefSeq Synonyms

NM_003639, NM_001321397, NM_001321396, NM_001145255, NM_001099857, NM_001099856, BC050612, BC046922, BC012114, BC000299,

Species

human

UniGene ID

Hs.43505

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.