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human IDS shRNA silencing AAV

Name 
AAV-h-IDS-shRNA
Cat No 
shAAV-211780
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human IDS.

shAAV-211780
AAV-h-IDS-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human IDS (iduronate 2-sulfatase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
MPS2; SIDS
Description (Vector)
Iduronate-2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this X-chromosome gene that result in enzymatic deficiency lead to the sex-linked Mucopolysaccharidosis Type II, also known as Hunter Syndrome. Iduronate-2-sulfatase has a strong sequence similarity with human arylsulfatases A, B, and C, and human glucosamine-6-sulfatase. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described.
Gene ID
3423
Gene Name (Vector)
iduronate 2-sulfatase
Gene Symbol
IDS
HGNC ID
HGNC:5389
ORF Size (aa)
939
ORF Size (bp)
939 bp
RefSeq ID
NM_000202
RefSeq Synonyms
NM_006123, NM_001166550, NM_000202, BC006170,
Species
human
UniGene ID
Hs.460960

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.