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human ICAM3 shRNA silencing AAV

Name 
AAV-h-ICAM3-shRNA
Cat No 
shAAV-211749
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human ICAM3.

shAAV-211749
AAV-h-ICAM3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ICAM3 (intercellular adhesion molecule 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CD antigen CD50; CD50; CDW50; ICAM-3; ICAM-R; intercellular adhesion molecule 3
Description (eCommerce)
ICAM-3 is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule [taken from NCBI Entrez Gene (Gene ID: 3385)].
Description (Vector)
ICAM3 is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule.
Gene ID
3385
Gene Name (eCommerce)
intercellular adhesion molecule 3
Gene Name (Vector)
intercellular adhesion molecule 3
Gene Symbol
ICAM3
HGNC ID
HGNC:5346
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1644
ORF Size (bp)
1644 bp
Protein Name (eCommerce)
Intercellular adhesion molecule 3
RefSeq ID
NM_002162
RefSeq Synonyms
NM_002162, NM_001320608, NM_001320606, NM_001320605, BC058903,
Research Areas
Immunology,Signal Transduction
Research Areas (Faceted)
signal_transduction,immunology
Species
human
Target Sentence
ICAM-3 is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule [taken from NCBI Entrez Gene (Gene ID: 3385)].
UniGene ID
Hs.654563
UniProt ID (eCommerce)
P32942

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.