human HYAL1 shRNA silencing AAV

Name
AAV-h-HYAL1-shRNA

Cat No
shAAV-211727

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human HYAL1.

shAAV-211727

AAV-h-HYAL1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human HYAL1 (hyaluronoglucosaminidase 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

HYAL-1; LUCA1; MGC45987; NAT6;

Description (Vector)

HYAL1 encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene ID

3373

Gene Name (Vector)

hyaluronoglucosaminidase 1

Gene Symbol

HYAL1

HGNC ID

HGNC:5320

ORF Size (aa)

1308

ORF Size (bp)

1308 bp

RefSeq ID

NM_007312

RefSeq Synonyms

NM_153285, NM_153283, NM_153282, NM_153281, NM_033159, NM_007312, BC035695,

Species

human

UniGene ID

Hs.75619

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.