human HSP90AB1 shRNA silencing AAV

Name
AAV-h-HSP90AB1-shRNA

Cat No
shAAV-211615

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human HSP90AB1.

shAAV-211615

AAV-h-HSP90AB1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human HSP90AB1 (heat shock protein 90 alpha family class B member 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

D6S182; HSP84; HSP90B; HSPC2; HSPCB

Description (Vector)

HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1 (MIM 140571), an inducible form, and HSP90AB1, a constitutive form. Other HSP90 proteins are found in endoplasmic reticulum (HSP90B1; MIM 191175) and mitochondria (TRAP1; MIM 606219) (Chen et al., 2005 (PubMed 16269234)).(supplied by OMIM, Aug 2008)

Gene ID

3326

Gene Name (Vector)

heat shock protein 90 alpha family class B member 1

Gene Symbol

HSP90AB1

HGNC ID

HGNC:5258

ORF Size (aa)

2175

ORF Size (bp)

2175 bp

RefSeq ID

NM_007355

RefSeq Synonyms

NM_007355, NM_001271972, NM_001271971, NM_001271970, NM_001271969, BC068474, BC016753, BC014485, BC012807, BC004928,

Species

human

UniGene ID

Hs.689683

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.