human HSD3B7 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human HSD3B7.
shAAV-211586
AAV-h-HSD3B7-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human HSD3B7 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CBAS1; PFIC4; SDR11E3
Description (Vector)
HSD3B7 encodes an enzyme which is involved in the initial stages of the synthesis of bile acids from cholesterol and a member of the short-chain dehydrogenase/reductase superfamily. The encoded protein is a membrane-associated endoplasmic reticulum protein which is active against 7-alpha hydrosylated sterol substrates. Mutations in this gene are associated with a congenital bile acid synthesis defect which leads to neonatal cholestasis, a form of progressive liver disease. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
80270
Gene Name (Vector)
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
Gene Symbol
HSD3B7
HGNC ID
HGNC:18324
ORF Size (aa)
1110
ORF Size (bp)
1110 bp
RefSeq ID
NM_025193
RefSeq Synonyms
NM_025193, NM_001142778, NM_001142777, BC004929,
Species
human
UniGene ID
Hs.709632
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.