human HRK shRNA silencing AAV

Name
AAV-h-HRK-shRNA

Cat No
shAAV-211528

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human HRK.

shAAV-211528

AAV-h-HRK-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human HRK (harakiri, BCL2 interacting protein). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

DP5; HARAKIRI

Description (Vector)

Activator of apoptosis Hrk regulates apoptosis through interaction with death-repressor proteins Bcl-2 and Bcl-X(L). The HRK protein lacks significant homology to other BCL2 family members except for an 8-amino acid region that was similar to the BCL2 homology domain-3 (BH3) motif of BIK. HRK interacts with BCL2 and BCLXL via the BH3 domain, but not with the death-promoting BCL2-related proteins BAX, BAK, or BCLXS. HRK localizes to membranes of intracellular organelles in a pattern similar to that previously reported for BCL2 and BCLXL.

Gene ID

8739

Gene Name (Vector)

harakiri, BCL2 interacting protein

Gene Symbol

HRK

HGNC ID

HGNC:5185

ORF Size (aa)

273

ORF Size (bp)

273 bp

RefSeq ID

NM_003806

RefSeq Synonyms

NM_003806, BC111923,

Species

human

UniGene ID

Hs.87247

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.