human HOXB4 shRNA silencing AAV

Name
AAV-h-HOXB4-shRNA

Cat No
shAAV-211456

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human HOXB4.

shAAV-211456

AAV-h-HOXB4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human HOXB4 (homeobox B4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

HOX-2.6; HOX2; HOX2F

Description (Vector)

HOXB4 is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.

Gene ID

3214

Gene Name (Vector)

homeobox B4

Gene Symbol

HOXB4

HGNC ID

HGNC:5115

ORF Size (aa)

756

ORF Size (bp)

756 bp

RefSeq ID

NM_024015

RefSeq Synonyms

NM_024015, BC049204,

Species

human

UniGene ID

Hs.664706

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.