human HOOK1 shRNA silencing AAV

Name 
AAV-h-HOOK1-shRNA
Cat No 
shAAV-211424
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human HOOK1.

shAAV-211424
AAV-h-HOOK1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human HOOK1 (hook microtubule tethering protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
hHK1; h-hook1; HK1; hook homolog 1; protein Hook homolog 1
Description (eCommerce)
HOOK1 is required for spermatid differentiation. It is probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). It is a component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) [taken from NCBI Entrez Gene (Gene ID: 51361)]. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9UJC3].
Description (Vector)
HOOK1 encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It is thought to link endocytic membrane trafficking to the microtubule cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined.
Gene ID
51361
Gene Name (eCommerce)
hook microtubule tethering protein 1
Gene Name (Vector)
hook microtubule tethering protein 1
Gene Symbol
HOOK1
HGNC ID
HGNC:19884
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2187
ORF Size (bp)
2187 bp
Protein Name (eCommerce)
Protein Hook homolog 1
RefSeq ID
NM_015888
RefSeq Synonyms
NM_015888, BC011621,
Research Areas
Cytoskeleton,Lysosomal Transport,Spermatogenesis
Research Areas (Faceted)
cell_biology,developmental_biology
Species
human
Target Sentence
HOOK1 is required for spermatid differentiation. It is probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). It is a component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) [taken from NCBI Entrez Gene (Gene ID: 51361)]. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9UJC3].
UniGene ID
Hs.378836
UniProt ID (eCommerce)
Q9UJC3

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.